PICSI in Mexico
At Instituto Mexicano de Infertilidad (IMI), we know that the foundation of a healthy pregnancy begins at the cellular level. That’s why we offer Physiological Intracytoplasmic Sperm Injection (PICSI)—an advanced version of ICSI designed to select the most mature and genetically stable sperm for fertilization.
PICSI represents the next evolution of assisted reproduction. By mimicking the natural process through which sperm bind to the egg, IMI’s embryologists ensure that only sperm with the highest potential for successful fertilization and embryo development are chosen.
What Is PICSI?
PICSI (Physiological ICSI) is a refinement of traditional ICSI. Instead of selecting sperm visually under a microscope, PICSI uses a hyaluronic acid (HA)–coated dish to identify sperm that are mature, biochemically competent, and less likely to carry DNA damage.
These selected sperm are then injected into the egg during IVF, resulting in:
- Improved embryo quality
- Higher fertilization and implantation rates
- Reduced miscarriage risk
Why Choose IMI for PICSI
- State-of-the-art embryology lab with precision micromanipulators.
- Highly trained embryologists experienced in HA-binding analysis.
- Comprehensive male infertility protocols.
- Affordable international pricing with no wait time.
- Holistic, patient-centered care that blends science and compassion.
Selecting the Healthiest Sperm for the Healthiest Embryos
In natural conception, sperm bind to the hyaluronic acid layer surrounding the egg (the cumulus oophorus). Only mature sperm with intact membranes and optimal DNA integrity can attach to this layer.
PICSI reproduces this step in the lab using HA-coated microdots:
- Immature or damaged sperm cannot bind to the HA surface.
- Mature, healthy sperm adhere naturally, allowing embryologists to easily identify and select them.
This ensures that only the best candidates are used for fertilization—naturally screening out those that might lead to failed implantation or miscarriage.
Advantages of PICSI
- 🧬 Improves sperm DNA quality — filters out immature or fragmented sperm.
- 💛 Reduces miscarriage risk — healthier sperm lead to stronger embryos.
- 🌿 Enhances implantation rates when combined with PGT-A.
- 👶 Increases live birth success in patients with previous IVF failure.
- ⚕️ Mimics natural fertilization, respecting biological processes.
How PICSI Works at IMI
Why You Should Choose IMI?
IMI Mexico combines world-class fertility expertise, advanced reproductive technology, transparent and compassionate care, and proven success in complex cases — all within a modern, internationally trusted clinic in Guadalajara.
When Is PICSI Recommended?
PICSI is especially helpful for:
- Couples with repeated IVF or ICSI failures.
- Men with abnormal sperm morphology.
- High sperm DNA fragmentation.
- Recurrent early miscarriages.
- Cases with unexplained infertility.
IMI’s fertility team may also recommend PICSI as part of advanced male infertility treatment in combination with PGT-A or ICSI.
Success Rates
Fertilization Technique | Average Clinical Pregnancy Rate | Miscarriage Rate |
ICSI | 60–70 % | 18–20 % |
PICSI | 70–80 % | 8–12 % |
IMI’s data shows that PICSI can nearly double implantation rates in patients with prior failed cycles.
Cost of PICSI
Treatment | Average Cost (USD) |
ICSI Add-On | $1 000 – $1 500 |
PICSI Add-On | $1 500 – $1 800 |
IVF + PICSI Package | $7 000 – $9 000 |
IMI offers transparent, bundled pricing for international patients, with all procedures performed under ISO-certified lab conditions.
PICSI vs. Traditional ICSI
Feature | ICSI | PICSI |
Sperm Selection | Visual | Biological (HA binding) |
DNA Integrity | Variable | Higher |
Miscarriage Risk | Slightly higher | Lower |
Cost | Moderate | Slightly higher |
Ideal For | Male infertility | Recurrent IVF failure, DNA fragmentation |
PICSI doesn’t replace ICSI—it enhances it. By adding an extra layer of natural screening, IMI increases both the safety and efficiency of every IVF cycle.
Integration with Other Treatments
PICSI can be combined with:
- PGT-A Genetic Testing – ensures embryo chromosomal normality.
- Egg Donation – improves outcomes with donor oocytes.
- Tandem IVF – dual-egg strategy for better yield.
- Fertility Preservation – sperm and embryo freezing after selection.
Learn more about ICSI in Mexico and Advanced Fertility Treatment.
International Treatments
Patients from the U.S., Canada, and Latin America choose IMI for PICSI because of:
- Comparable technology to U.S. and European clinics.
- Multilingual staff and international coordination.
- Quick cycle turnaround (10–14 days).
- Relaxed recovery in Mexico’s most scenic destinations.
Q1. Is PICSI better than ICSI?
Q2. Does PICSI increase pregnancy chances?
Q3. Is PICSI safe?
Q4. Can PICSI be used with frozen sperm?
Q5. How long does the procedure take?
Johannes Times
Rachel Jackson